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However, excellent SOD activity alone is not sufficient to scavenge excessive ROS, and carbon-dot nanozymes with multiple cascade-like activities are of greater value for further research and development

doi: 10.1021/tx0256127

Cholesterol is another important lipid and its hydroperoxides are produced solely by non-enzymatic oxidation, the major products being cholesterol 7-hydroperoxide and 5-hydroperoxide by free radicals and singlet oxygen, respectively

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Drug repurposing screens using computational approaches, patient-derived models, and biobank analyses are identifying additional candidates for metabolic targeting in NSCLC [88,89,90,91]

This was to be expected, as the trial had planned a long-enough wash-out of 28 days between the two periods of the cross-over trial