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2014;5(12):e1576

We confirmed that strong disulfide stress responses are caused by HOCl in different Gram-positive bacteria in vivo and detected mixed protein disulfides with Cys, BSH, and MSH as major oxidation products (Chi et al., RNS cause reversible thiol-modifications: nitric oxide (NO) leads to S -nitrosothiol formation (RS-NO) and peroxinitrite (ONOO ) causes S -nitrothiol (RS-NO 2 ) formation

Many studies have confirmed that quercetin, a ROS scavenger, can improve redox balance and mitochondrial homeostasis by blocking H 2 O 2 and reversing mitochondrial Mn SOD activity, thereby reducing myocardial hypertrophy ( in vitro experiment of cisplatin induced cardiac toxicity, it was found that H9c2 cardiomyocytes treated with 40 M quercetin significantly decreased their myocardial cytotoxicity, which may be related to the Nrf2/HO-1 and P38MAKP/NF-Bp65/IL-8 signal pathway (Table 6)

The pyruvate dehydrogenase complex at the epigenetic crossroads of acetylation and lactylation

Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia