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No mechanism of action explains how b12 would reduce nausea caused by delayed gastric emptying
Activated cisplatin preferentially binds to purine bases in the nucleophilic N7 sites, where the majority of adducts occur between two guanines on the same strand, whereas ~35% of cisplatin adducts react with purines at the opposite strands, forming interstrand crosslinks (ICLs)
After the reaction is complete, take 0.5 mL of the reaction mixture, add the DTNB working solution, and allow to react for 5 minutes at 25C
Coadministration of warfarin should be monitored carefully
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