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In addition, there are genetic predispositions that cause variations in genes (GSS, GCLC, GCLM) encoding enzymes critical for the glutathione synthesis pathway

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7.5 Critical discussion of translational challenges The translation of ferroptosis-targeting agents for AD faces multiple interconnected challenges, with BBB penetration, off-target effects, long-term safety, and perturbations of iron metabolism and immune function being the most prominent

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CD5/ LNP-FAPCAR 2.2, IgG/ LNP-FAPCAR 2.2, or saline was injected into BLM mice at postoperative days 7 and 14