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A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity

Specifically, pernicious anemia is anemia caused by a deficiency of vitamin B12 due to a lack of absorption

Am J Physiol Lung Cell Mol Physiol 298: L404L416, 2010

GIP is a hormone that may complement the effects of GLP-1 receptor agonism

This is primarily driven by the high comorbidity of PSC with inflammatory bowel disease (IBD), a clinical syndrome that is often referred to as PSC-IBD, with over 70% of patients with PSC either having or at risk for developing IBD

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