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For stroke, a trial of ebselen treatment and stroke showed some promising results of ebselen in improving outcomes [110], however this study has not been replicated and there is no clear association of stroke risk or outcomes with GPx1 polymorphisms [111, 112]

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Previous research has highlighted the critical role of IL-7 in cell survival and proliferation, mediated through the phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway (71)

Emerging evidence suggests that a cocktail approach, that is, incorporating not only senolytics and senomorphics but also other therapeutic modalities, such as antioxidants, immune modulators, or metabolic enhancers may have a compounded effect in promoting healthy aging.261 Future clinical trials should explore these combination strategies, testing them in diverse age-related diseases to understand the potential for synergy and minimizing possible negative interactions between therapies