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2004 Apr;5(4):43640

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Thats a far bigger concern than many people realise. Unlike licensed medicines, products sold through unregulated online suppliers may vary significantly in purity, concentration and quality

Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)

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doi:10.1046/j.1365-2230.2002.01085.x