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While there is no corroborative clinical trial data, animal experiments suggest that hydroxocobalamin produces a time and organdependent, selective regulation of nitric oxide synthases during endotoxemia and regulates downstream inflammatory mediators, thereby having a potential role in the treatment septic shock 4

[13] Such dosing is intended to reverse life-threatening seizures and metabolic effects by restoring adequate coenzyme levels

Theres insufficient safety data on GHK-Cu in pregnancy or breastfeeding

Yazaki Y, Chow G, Mattie M

High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited

But quite a number who wrote in to me using felt they did