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The GLP1R variant rs10305420 is a missense variant in the signal peptide region, and may influence stability of the peptide secondary structure (Extended Data Fig
however, this has not been rigorously demonstrated in controlled human studies
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The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study
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