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The PI3K/Akt pathway activated by IGF1R is a major anti-apoptotic pathway in neurons, which drives interest in IGF1R agonism as a potential neuroprotective strategy in preclinical research

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Key risk factors for NA-AION include arterial hypertension, coronary heart disease, hyperlipidemia, male gender, sleep apnea, diabetes mellitus, factor V Leiden heterozygosity, and a history of cardiovascular medication use [524]
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