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TABLE 1 Potential candidates of drug repositioning for CIPN identified in preclinical studies Cytochrome-P 450 -epoxygenase 2J (CYP2J), High-mobility group box 1 (HMGB1), N -methyl-d-aspartate receptor (NMDAR), nuclear factor-erythroid-2-related factor 2 (Nrf2), organic anion-transporting polypeptide B2 (OATP1B2), organic cation transporter 2 (OCT2), phosphodiesterase (PDE), peroxisome proliferator-activated receptor gamma (PPAR), sphingosine 1-phosphate (S1P), store-operated calcium entry (SOCE), superoxide dismutase (SOD), potassium channel subfamily K member 2 (TREK1), transient receptor potential channel melastatin 8 (TRPM8)

Through a series of enzymatic reactions, a small protein molecule composed of 76 amino acid residues, ubiquitin, is attached to target proteins, ultimately leading to changes in the proteins localization and function or its degradation by the proteasome ( Figure 1 )

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