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It has been well established that GM can affect brain trough GBA, which is a bidirectional communication between the gut and the brain, involving the immune, endocrine and nervous system

[DOI] [PubMed] [Google Scholar] 195.Zemba Cilic A., Zemba M., Cilic M., Strbe S., Ilic S., Vukojevic J., Zoricic Z., Filipcic I., Kokot A., Smoday I.M., et al

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Acknowledgements We acknowledge the DSFP contract, King Saud University, Riyadh, KSA (to SYA) and the Slovak Grant Agencies VEGA Project 1/0482/20 and APVV Project 19-0087

Tesofensine targets the LH, silencing a subset of GABAergic neurons Tesofensine is more efficacious in inducing weight loss in obese rats than lean Wistar rats
