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Information for Patients: Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B 12 for the remainder of their lives

When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

doi: 10.1056/NEJM197111182852108

This does not support a functional role of B12 in cancer initiation or progression, but rather suggests that elevated B12 could be an epiphenomenon in some cancers

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Unlike some peptides that can be used indefinitely, AOD-9604 benefits from defined use periods followed by breaks