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Upon binding to biologically active HGF, c-Met undergoes dimerization and recruits downstream signaling effector molecules, including PI3K, PLC-?1, and STAT3

Walsh emphasizes that zinc-dependent adenosine metabolism is an important downstream step

GSH was nominated for the 503B bulk drug substances list and is under evaluation by the FDA

A conservative correlation coefficient ( R ) estimate (0.9) was used (Borenstein et al., 2021)

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Final products are lyophilized under controlled conditions to preserve stability and minimize degradation