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For example, when using RSL3a canonical ferroptosis inducer through inhibition of GPx4GPx1 cannot compensate for the loss of GPx4 since its main substrates are hydroperoxides whereas GPx4 reduces lipid peroxides [19]

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Amiri S, Sepahvand S, Radi M, Abedi E

Once-weekly cagrilintide for weight management in people with overweight and obesity: A multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

While useful for measuring small intestinal permeability, lactulose, mannitol and L-rhamnose are all fermented by the gut microbiota when they reach the colon and are thus unreliable for the assessment of specifically colonic permeability

Its results in PD, however, remain controversial