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doi:10.1016/j.jcis.2020.05.005 57

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In addition, in a rodent model of cardiac arrest induced by potassium chloride, NAM significantly increased survival and reduced NAMPT concentration in blood [190], which may lead to decreased inflammation, as elevated blood NAMPT levels have been related with inflammatory disorders [191]

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Studies on mice models showed that a high-fat diet correlates with decreased GLP-1 production, reduced GLP-1 receptor sensitivity, impaired ghrelin secretion, and sensitivity, thus determining a diet-induced low-grade organ-specific and systemic inflammation [28]

Compared to FoB, MZB were previously shown to use GSH through Gpx4 for protection from excessive lipid peroxidation 33 , suggesting a differential dependency on redox functions downstream of GSH synthesis