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Although direct evidence is currently limited, several transgenic animal studies have suggested a potential role for ferroptotic damage in initiating tumorigenesis

153 Notably, PGRN levels in patient serum mirror those in tumor tissues, with higher expression linked to poorer overall and disease-free survival, particularly in LGGs

The reaction contained 3.5 mM sulfoxide substrate 4 , 165 mM cyclohexane-1,3-dione in 100 mM KPi buffer, pH 8.0, was initiated by the addition EgtE to a final concentration of 4.0 M (A)