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In OmWAT, there was a significant negative correlation between B12 and gene expression of ACACA, FASN, SCD, GPAT2, LIPIN1, and DGAT2 (Fig

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[PubMed] [Google Scholar] 92.Minigalieva I.A., Katsnelson B.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Shur V.Y., Shishkina E.V., Valamina I.E., Makeyev O.H., Panov V.G., et al

In a study of patients with chronic low back pain, Vitamin B12 given for 2 weeks reduced pain by 32% compared to placebo [Chiu, 2011] In a 2020 systematic review looking at the use of B12 for nerve-related pain it was found that there is moderate evidence for the therapeutic effect of B12 in the treatment painful peripheral neuropathy [Julian, 2020]