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J Clin Invest (1994) 94(4):14905

Thus, individuals taking methotrexate may have an increased choline requirement

If your semen analysis flagged morphology issues, that matters because abnormally shaped sperm cells 11 can understandably lead to fertility challenges, making it harder for the sperm to reach and penetrate the egg

It can cause diarrhea and intestinal discomfort with high doses

Any studies that do exist tend to be small
