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Preclinical studies have shown promising results: Specific strains such as Bifidobacterium breve and Lactobacillus plantarum reduce microglial activation, increase anti-inflammatory cytokines like IL-10, promote neurogenesis, and enhance cognitive performance in rodent models of AD [624, 625]

Importantly, microglia in this activated state also secrete pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further amplify ROS production and reinforce the inflammatory state

Advising patients to take their tablets after meals can help to relieve this