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doi: 10.1038/s41467-021-21924-8

Alessandro Sacco, University of Catanzaro, Italy Updates Copyright 2022 Pei, Qian, Wang and Tan

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Macrophages significantly attenuated the lipid peroxidation of epithelial cells

DRG-specifically enriched lncRNA (DS-lncRNA) highly expressed in DRG neurons was significantly downregulated following L4 SNL, CCI, or axotomy of the unilateral sciatic nerve, increasing the expression of Ehmt2 /G9a triggered by the transcription cofactor RALY/RNP II, which correspondingly reduced the expression of opioid receptors and Kcna2 in related DRGs, contributing to NP [112]

While MG production can result from protein and lipid metabolism (Fig 1B), glycolysis is the most important source of endogenous MG (Fig 1A) [7]