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The honest research caveat is that "theoretically additive" is not "experimentally additive" and a researcher who needs to claim synergy must run the combination versus the components in their own model

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Transport of Thyrotropin Releasing Hormone in Rabbit Buccal Mucosa In Vitro

10.1002/pd.4966 56 KurossS

We cant stress this enoughyou must protect it from temperature extremes
