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Post-marketing surveillance depends on voluntary reporting and is designed poorly to detect gradual, cumulative effects

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Cellular studies of the inhibitory capacity of CLR01 in two different models suggested that the molecular tweezer could reduce the toxicity of endogenously expressed and aggregated -Syn and decrease the administrations toxic effect of exogenous -Syn oligomers, increasing the cell viability [306]

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Animal models show multiple effects of vitamin B12 that are likely of clinical relevance, including the potential to support nerve regeneration, which could result in long-term healing beyond immediate pain-reducing effects
