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Acknowledgements We thank Alainaa Refaie and Dessalegn Lamesgen Chnie, who have polished the manuscript

doi: 10.1016/S0167-8140(01)00358-9

The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells

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doi: 10.1136/bmj.h4183