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Myc signaling also results in protecting cells from platinum-induced ROS toxicity by activating a mitochondrial methyl transferase ( SHMT2 ), which results in elevated NADPH [104], and by activating NFE2L2/NRF , a master transcription factor regulating ROS-detoxifying enzymes [48]

SL: Methodology, Writing review & editing

Similarly, earlier studies led by Sikiric and colleagues in the 1990s suggested safety and benefit in gastrointestinal conditions such as ulcerative colitis, but these reports were published only in abstracts or local conference proceedings, with no independent replication or peer-reviewed validation