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Accumulation of electrophilic aldehydes during postovulatory aging of mouse oocytes causes reduced fertility, oxidative stress, and apoptosis
found that dietary Gln supplementation can elevate Gln levels in the TME, decrease the expression of immunosuppressive genes such as Ctla4 and Nrp1 in Tregs, inhibit Treg differentiation, and consequently enhance the tumor immune response (52)
Recent work has shown that human ZIP4 is able to transport Cu (II) with micromolar affinity when expressed in oocytes (Antala & Dempski, 2012)
V.GmezA.Di StefanoB.BerenguerC.et al (2018)
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