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In rare cases, it is also reported that prolong treatment with adefovir even in a low dose of 10 mg can cause adefovir-induced osteomalacia, a metabolic bone disease that leads to softening of the bones
doi:10.1155/2017/1297658

Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies

Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB
10.1186/s10194-021-01369-6 J

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