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Disturbances in the balance between pro- and anti-angiogenic factors can drive pathologic angiogenesis ( Physiologic Angiogenesis: Process and Types Blood vessels of the microvasculature are composed of two major cell types: endothelial cells and perivascular cells known as pericytes (Mazurek et al., 2017)

Application protocol: Product: Hydrocortisone 1% cream (available at any pharmacy without prescription) Timing: Apply after noticing the reaction, not before injection Amount: Thin layer covering the entire affected area plus a 1-centimeter margin Frequency: Twice daily (morning and evening) until the reaction resolves Duration: Typically 2 to 5 days, do not use for more than 7 consecutive days without medical guidance Important: Do NOT apply hydrocortisone before injection, as it can interfere with medication absorption For reactions that do not respond to 1% hydrocortisone, a healthcare provider can prescribe stronger topical corticosteroids (triamcinolone 0.1% or betamethasone 0.05%)

Glutathione GSH (L--glutamyl-L-cysteinyl-glycine) is a non-protein thiol that reaches millimolar concentrations in most cell types

RW F, Meeker AD, Cady PS, Culbertson VL, Force WS, Kelley CM

[DOI] [PubMed] [Google Scholar] 20.Liao K., Foster P., Seitz L., Cheng T., Gauthier K., Lawson K., Jin L., Paterson E

Jul 2014;59(1):43-48