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Description
The nausea typically emerges within 1-2 days of injection and resolves within 48-72 hours
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In contrast, the MyD88independent pathway is mediated by TRIF [TIR domaincontaining adaptor inducing interferon (IFN )] and TRAM (TRIFrelated adaptor molecule) to induce expression of type I IFNs.13 It is beyond the scope of this review to cover these pathways in detail hence we refer readers to the multiple reviews that explain the TLR4 signalling pathway in depth.10, 11, 14, 15 Although PKC isoforms are involved at many levels of the TLR signalling cascade, we will focus on the involvement of PKC in TLR4 signalling as PKC is implicated as an important player in the TLR4 signalling pathway during macrophage activation.7 The role of PKC in host defence against bacterial infection was revealed through studies in PKC knockout mice, where mice lacking PKC have a diminished response to lipopolysaccharide stimulation, characterized by low levels of several cytokines, namely tumour necrosis factor and IL1 .16 Other studies show PKC playing a role in both the MyD88dependent and MyD88independent pathways of TLR4 signalling (Fig
Injecting at night without subsequent UV exposure wastes the dose
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