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High blood sugar levels due to poor insulin use (high glucose levels) can damage endothelial cells the cells lining blood vessels, lymphatic vessels, and organs and cause oxidative stress

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Bacteria that are overrepresented in PD include Akkermansia , Bifidobacterium , and Lactobacillus , and opportunistic/potential pathogens Enterococcus (endotoxin-producing) Christensenella , Oscillospira , Corynebacterium , Alistipes , some Bacteroides , Megasphaera , Desulfovibrio , Streptococcus , Staphylococcus , and the family Enterobacteriaceae ( E