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Identification of novel human nicotinamide N-methyltransferase inhibitors: a structure-based pharmacophore modeling and molecular dynamics approach

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In practical applications, individualized adjustments should be made based on animal weight, physiological status, and severity of the disease

1-MNA 1-methyl nicotinamide NNMT is predominantly expressed in the liver, but modest levels of the enzyme are also present in other tissues, including the adipose tissue, kidney, brain, lung, heart, and muscle

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