glutathione depletion methylation cycle block Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice N-Acetyl-Cysteine supplementation lowers high homocysteine
Description
When metabolic stress occurs, MOTS-c in cells can be transferred to the nucleus in an AMPK-dependent manner and bind to transcription factors regulated by ARE, thus improving the stress resistance of cells (16, 24)

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doi: 10.1002/syn.21546

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