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The uncontrolled generation of GSSG during oxidative stress can contribute to mitochondrial dysfunction by glutathionylation of target proteins, as described below

While it is accurate, it is also costly and relatively slow, limiting its use for large sample materials

In 2021, Sun and colleagues reported a pioneering library of cereblon-based PROTACs targeting the degradation of glycogen synthase kinase 3 (GSK-3), a protein kinase considered a therapeutic target in neurodegenerative diseases

[DOI] [PMC free article] [PubMed] [Google Scholar] 207.Hayes J.D., Flanagan J.U., Jowsey I.R

[DOI] [PubMed] [Google Scholar] 11.Jaeschke H, Wendel A

Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis