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These animal models are extremely valuable for investigating the potential underlying pathophysiology of SZ, however they are also hampered by challenges relating to species differences

While supplementation can increase plasma carnitine levels and might improve fatty acid oxidation and nitrogen balance, there is no definitive evidence that it significantly impacts important clinical outcomes like weight gain, survival, or long-term health

Shroff, G

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Biological pathways such as the TCA cycle, oxidative stress as reflected in glutathione metabolism, and systemic inflammation have been identified in people with DCM and/or heart failure and in relevant tissue from other species (i.e., heart muscle in a hamster model of DCM) 23,25,39,40,41 , and were confirmed in the current study

Sudtis