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In non-pathologic conditions, the cortex activates the indirect pathway with a smaller contribution of inhibition through SNpc dopamine release on D2-receptor cells in the striatum

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Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI

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