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Lower in vitro neutralization titers of sera from convalescent and vaccinated individuals are consistent with reduced effectiveness of vaccines in use against Omicron and other variants 28,29

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At the metabolomics level, the fatty acid biomarkers identified include capric acid, caproic acid, propionic acid, and heptanoic acid and showed a significant reduction in at least one of the severity groups listed above, compared to the healthy controls and the concentration of the uremic toxins IS and p-CS were significantly high at the advanced stage