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The fluence (energy per unit area) must be sufficient to raise follicular temperatures to lethal levels while remaining below the threshold for epidermal damage

Protracted and excessive ERS may contribute to the progression of various diseases [92]

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While the major SURMOUNT trials primarily examined weekly dosing protocols, emerging clinical evidence and real-world data support twice-weekly schedules as an effective alternative for patients who tolerate more frequent injections or experience better appetite suppression with this frequency

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