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Interestingly, this led to the suggestion that, since no targeted therapy has been developed to date for Marfan syndrome, the prevention or reversal of the SirT1 GS-ylated state may represent a new therapeutic strategy to prevent the dissection/rupture of the TAA in these subjects [55]

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Reville PK, Sasaki K, Kantarjian HM, Daver NG, Yilmaz M, Dinardo CD, Short NJ, Borthakur G , Pemmaraju N, Mehta RS, Pierce S, Konoplev SN, Khoury JD, Garcia-Manero G, Konopleva MY, Jabbour E, Ravandi F, Kadia TM

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