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This depth primarily enhances absorption of topicals

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doi: 10.1016/S0016-5085(09)61912-0

Glutamate-cysteine ligase (GCL) Combines glutamate and cysteine to form gamma-glutamylcysteine

The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions