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2-PMPA derivatives masked with two, three, or four ODOL groups were synthesised and evaluated for in vitro stability and in vivo pharmacokinetics in mice and dogs (Dash et al., 2019)

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The 50% effective concentrations (EC 50 ) ranged from 0.02 to 1.7 nM

The expression of occludin, a protein involved in maintaining tight junction barrier properties, glial cell-derived neurotrophic factor (GDNF), associated with spermatogonial self-renewal, and transforming growth factor-beta (TGF-), implicated in injury repair processes, were analyzed in Sertoli cells

It works by blocking adenosinea compound that promotes relaxationthereby encouraging wakefulness and sharper focus[9 Trusted Source 2015 - Current neuropharmacology Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug