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They are phospholipid bilayer-enclosed vesicles, secreted by stem cells, and they contain bioactive molecules (proteins, mRNA and miRNA) inside (Thry et al., 2002)

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10.1038/mi.2014.35 8 ChenJ.XuF.RuanX.SunJ.ZhangY.ZhangH.et al (2023a)

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Factors associated with successful continuation include proper dose escalation, proactive side effect management, dietary modifications, and realistic expectations about the transient nature of symptoms