glutathione is an Top 8 Rich Foods For Glowing & Healthy Skin What is glutathione and why

Its dysfunction leads to GSH depletion, rendering GPX4 unable to effectively exert its antioxidant function even with adequate expression (Wu et al., 2025a

However, its chemical composition is very similar to its parent molecule, collagen (8)

doi: 10.1210/jendso/bvaa075 30 ElseTKimACSabolchARaymondVMKandathilACaoiliEMet al

J Biomed Mater Res B Appl Biomater 108(5):20732087

doi: 10.3390/pharmaceutics15010059

decreasing its association with desuccinylase SIRT2 and succinyltransferase P300, respectively, leading to a fast GCLC activation and consequently increased GSH synthesis, which endows cancer cells with phenotype of resistance to ferroptosis under oxidative stress condition (Fig