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Important Safety Information CONTRAINDICATIONS: Individuals known to have severe, potentially life-threatening reaction to human globulin preparations should not receive HepaGam B or any other immune globulin (human)

The combination leads to severe drowsiness, increased liver stress, and a higher risk of adverse reactions

The clinical consequence ranges from local inflammation through to systemic hypersensitivity and antibody formation

Vegans and vegetarians are at particular risk, since B12 is found almost entirely in animal products

There is a previous report that methylglyoxal interferes with GSH synthesis and secretion [18], which could be why methylglyoxal treated cells show a lower level of GSH, compared to control and CoCl 2 treated cells