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Physical activity in mice exposed to particulate matter (PM) paradoxically had a protective effect, reducing oxidative stress, apoptosis, and inflammation in lung tissue, despite increased inhalation of pollutants due to exercise-induced hyperventilation [79]

L2-Cmu treatment improves female cardiac function Given the reported importance of IGF-1 signaling to the myocardium 27,28 , we next assessed the effects of IGF-1R antagonism on cardiovascular function by echocardiography (Fig

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7), and beta cell mass (see ESM Methods and ESM Fig