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Summarizing the data on the mechanisms of necroptosis, it can be noticed that this kind of programmed cell death requires mitochondrial and cytosolic ROS [216, 217]

However, due to the deregulation of cells and increased cell death, glutathione deficiency is often observed in those with autoimmune diseases, arthritis, asthma, and even Parkinson's disease

444 Curcumin is being evaluated as a radiosensitizer in prostate (NCT01917890) and cervical cancer (NCT05947513) but faces challenges due to its low bioavailability, short half-life, and HIFs, necessitating nanoparticle-based delivery systems

Development and validation of a novel diagnostic model for childhood autism spectrum disorder based on ferroptosis-related genes

Beyond direct H 2 O 2 scavenging, GSH also detoxifies lipid peroxidation byproducts, including malondialdehyde (MDA) and 4-HNE, through GST-mediated conjugation, facilitating their removal and preventing secondary cytotoxic signaling 91,92

Disorders 16, 2241