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Therefore, future studies should investigate this possibility as the aberrant transport of BDNF may underlie neuronal loss and cognitive dysfunction observed in AD

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The prevalence of B12 deficiency in those older than 60 years is between 10% and nearly 20%.7,8 Because multiple causes can coexist in elderly patients, including poor absorption, protracted metformin use, and reduced dietary intake, these patients have the greatest risk for B12 deficiency and should be carefully monitored for signs of deficiency

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These peptides may be available through compounding pharmacies under specific circumstances or through research chemical suppliers, but such availability does not confer regulatory approval or imply safety and efficacy for human therapeutic use