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For the prevention of chronic diseases and cancer in which oxidative and inflammatory stress contributes to the pathogenesis, enhancing Nrf2 activity is still a traditional and effective approach

During cardiac stress, ischemic injury, and metabolic syndrome in the cardiovascular system, necrotic cells release DAMPs, which are recognized by pattern recognition receptors on innate immune cells, triggering strong inflammatory responses

Pediatr Allergy Immunol 24(5):501508

Once activated, NF-B translocates from cytoplasm to nucleus where it binds to the DNA promoter sequences of TNF-, IL-1, IL-6, COX-2, and iNOS (Maes 2009