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The prospects of natural sulfur compounds show great promise as they have potential applications in nutraceuticals, medicines, and functional foods to enhance brain function and prevent diseases

The most important ROS include superoxide anion, hydroxyl radical, and hydrogen peroxide (H 2 O 2 ), while the principal antioxidant enzyme systems are SOD, glutathione peroxidase, and catalase

This creates a favorable environment for tissue healing while reducing chronic inflammation that drives osteoarthritis progression

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Antioxidant supplements hold significant potential in mitigating ROS-mediated cellular and tissue damage, either by directly neutralizing free radicals, as seen with vitamins C and E, or by supporting enzymatic defense systems such as superoxide dismutase and catalase, which actively scavenge free radicals (Poljsak et al., 2013