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Gameiro, P

In vitro , myricetin treatment of SH-SY5Y neuroblastoma cells exposed to 1-methyl-4-phenylpyridine (MPP + ) significantly reduces Fe 2+ and ROS levels, activates the NRF2/GPX4 signaling pathway, suppresses neuronal ferroptosis, and mitigates cellular injury ( 2+ , ROS, and tumor necrosis factor alpha (TNF-), thereby suppressing neuronal ferroptosis and neuroinflammation and improving learning and memory performance

175 Furthermore, in breast cancer, tumors exhibiting high levels of imaging tumor heterogeneity are associated with a poor prognosis

Org Biomol Chem 13:38823886

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Lancet 396:12231249