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GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that GDF11 supplementation enhanced angiogenesis and cell migration, promoted protein phosphorylation, and activated the PI3K-AKT signaling pathway (Fig

Frames were taken every 30 min over 24 h

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These combined experiments, uncover some distinctive features between the GDF11 and GDF8 mature domains in vivo , suggesting that the endogenous mature ligands are functionally different